As mentioned earlier, you will get a different horizontal and vertical sensitivity. Stretched resolutions are only going to bring you headaches, I would definitely advice against using it unless you are only playing one specific game.
And by how much is it different? Well that depends on what exact aspect you want to match, do you want the same 360 distance, same tracking speed (MDV 0%) same flick speed to the edge (MDH 100%?) or what? For most games that support a separate vertical sensitivity the calculator gives you the option to accurate calculate this.
In other words, there is not one number that differentiates the stretched aspect ratio from the native.