It depends on what you want achieve, Hdeg 4:3 110 will calculated the FOV to be 110 for the 4:3 portion of the screen (making the 16:9 FOV 124.59), while Hdeg 16:9 will calculate 110 for the full 16:9 portion. In both cases it's important to check the output for the Config FOV you need to configure to get this FOV in the game. This is crucial for the sensitivity calculation to be accurate.