They all affect different aims so you can tailor your conversion based on your preference. The default settings should work fine for most people.
Normal is hipfire/default aim.
ADS is targeting, ADS and scopes below 2x.
Scope is scopes 2x and above.
Win/2D is any conversion with just a 2D cursor like Windows, osu and League of Legends.
MDH 0% is matching tracking speed, while 100% is matching flicks to the edge of the monitor. Which one you prefer is up to you, but most prefer 0%.